Driving research of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS),
Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia and Long Covid.

Donate
Sign Up
Main Menu

Biological Outlier and Subtyping
Software for Myalgic Encephalomyelitis

Study AIM

This project will develop a software tool to rapidly look for metabolism anomalies in an individual which might be explained by their genes. It will also look for potentially damaging genes in individuals and it will attempt to group ME/CFS patients based on their genetic and metabolic profiles.

LEAD INVESTIGATORS

  • Christopher Armstrong, PhD

  • Katherine Huang

  • Neil McGregor, PhD

Updates and Potential
  • Method optimisation complete and a systematic review compiling NMR metabolomics workflows employed in the literature has been published (click here).
  • Completed application for UK Biobank data: outcome successful.
  • Currently submitting and writing papers on UKB metabolism data to identify potential biomarkers between ME/CFS and healthy and co-morbidities.
STUDY HYPOTHESIS AND DESCRIPTION

The analytical tool will be developed using pre-existing UK Biobank gene and metabolism data from over 1000 self- reported ME/CFS patients. Findings from this data will then be validated on gene and metabolism data we produce ourselves from blood received from 300 ME/CFS patients recruited by the Australian ME/CFS Biobank.

This tool will be important in understanding the complexity of the individual with ME/CFS and may provide clues to potential missed diagnoses.

OBJECTIVES

  1. Observe the relationship between genes and metabolism to identify outlier genetic anomalies and pathways in ME/CFS.
  2. Determine the relationship between metabolism and genes in ME/CFS as compared to other similar diseases.
  3. Develop an algorithm to rapidly extract outlier and pattern pathways of disease.
  4. Test and validate algorithm produced on a well-curated set of ME/CFS patients with metabolism and gene data.
  5. Eventually produce software to simplify this process.
Other links you might be interested in:
Four Tips to Make Your Facebook Fundraiser a Success
The Ronald G. Tompkins ME/CFS Collaboration at the Harvard Affiliated Hospitals
Facebook Twitter Youtube Instagram Linkedin
OMF is a non-profit 501(c)(3) organization
(EIN# 26-4712664). All donations are tax-deductible to the full extent allowed by law.

Open Medicine Foundation®
29302 Laro Drive,  Agoura Hills, CA 91301 USA
Phone: 650-242-8669
info@omf.ngo

Contact Us

PRIVACY  |  COOKIE   |   CONSENT   |  MEDICAL & OTHER DISCLAIMERS

Copyright © 2023 Open Medicine Foundation. All Rights Reserved.

Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME / CFS) Post Treatment Lyme Disease Syndrome (PTLDS), Fibromyalgia Leading Research. Delivering Hope.Open Medicine Foundation®

What are the advantages of giving from your Donor Advised Fund (DAF)?

  • Your gifts to your donor advised fund entitle you to an immediate income tax deduction at the time of contribution.
  • You avoid capital gains tax on appreciated assets you place in your donor advised fund.
  • Your fund’s investment gains accumulate tax free.
  • Funds are distributed to Open Medicine Foundation in your name and immediately put to use to support our worldwide research efforts.

How do I make a donation through my DAF?

Just click on the DAF widget below. It is simple and convenient to find your fund among the over 900 funds in our system.

Still can’t find your fund? 

  • Request a grant distribution through your Donor Advised Fund sponsor
  • Be sure to use OMF’s EIN #26-4712664
  • You can also designate OMF as a beneficiary for your Donor Advised Fund
  • Questions? Give us a call at 650-242-8669 
 

Consent management

Consent Preferences

Data Subject Access Request (DSAR) Form 

Donate