Disease Mechanisms and Clonidine Treatment in Adolescent Chronic Fatigue Syndrome.

At baseline, patients with CFS had a lower number of steps per day, digit span backward score, and urinary cortisol to creatinine ratio. They had a higher fatigue score, heart rate responsiveness, plasma norepinephrine level , and serum C-reactive protein concentration compared with healthy controls. There were no significant differences regarding blood microbiology evaluation.

Adolescent CFS is associated with enhanced sympathetic nervous activity, low-grade systemic inflammation, attenuated hypothalamus-pituitary-adrenal axis function, cognitive impairment, and large activity reduction, but not with common microorganisms. Low-dose clonidine attenuates sympathetic outflow and systemic inflammation in CFS but has a concomitant negative effect on physical activity; thus, sympathetic and inflammatory enhancement may be compensatory mechanisms. Low-dose clonidine is not clinically useful in CFS.

Anxiogenic effect of subclinical bacterial infection in mice in the absence of overt immune activation

Gut pathogens can communicate with the CNS and influence emotional behaviors such as anxiety and depression, even at extremely low levels and in the absence of an immune response.
Mice were orally infected with Campylobacter jejuni and Citrobacter rodentium. The measured IL-6 and leukocytes showed no clear immune response to this infection, but the mice had altered levels of anxiety-like behavior. If you are depressed or have anxiety it could possibly help to alter your gut microbes and add pro/prebiotics to your diet.