Anxiogenic effect of subclinical bacterial infection in mice in the absence of overt immune activation

Gut pathogens can communicate with the CNS and influence emotional behaviors such as anxiety and depression, even at extremely low levels and in the absence of an immune response.
Mice were orally infected with Campylobacter jejuni and Citrobacter rodentium. The measured IL-6 and leukocytes showed no clear immune response to this infection, but the mice had altered levels of anxiety-like behavior. If you are depressed or have anxiety it could possibly help to alter your gut microbes and add pro/prebiotics to your diet.